SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934

(Amendment No.     )

SURROZEN, INC. (F/K/A CONSONANCE-HFW ACQUISITION CORP.)

(Name of Issuer)

Common Stock, $0.0001 par value per share

(Title of Class of Securities)

86889P 109

(CUSIP Number)

James Evangelista

Chief Financial Officer

The Column Group III, LP

1 Letterman Drive, Building D, Suite M-900

San Francisco, CA 94129

(415) 865-2050

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

August 11, 2021

(Date of Event Which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box  ☐.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

(Continued on following pages)

Item 1. Security and Issuer.

This joint statement on Schedule 13D (this “Statement”) is filed with respect to the Common Stock, par value $0.0001 per share (“Common Stock”), of Surrozen, Inc, a Delaware corporation (the “Issuer”). The address of the principal executive offices of the Issuer is 171 Oyster Point Blvd., Suite 400 South San Francisco, CA 94080.

Item 2. Identity and Background.

(a) This Statement is being filed by The Column Group III, LP (“TCG III LP”), The Column Group III-A, LP (“TCG III-A LP”) and The Column Group III GP, LP (“TCG III GP LP” together with TCG III LP and TCG III-A LP, the “Reporting Entities”) and Tim Kutzkey (“Mr. Kutzkey”), a member of the Issuer’s board of directors (the “Board”). The Reporting Entities and Mr. Kutzkey are collectively referred to as the “Reporting Persons.” The agreement among the Reporting Persons to file jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act is attached hereto as Exhibit 1. Each Reporting Person disclaims beneficial ownership of all securities reported in this Statement except to the extent of such Reporting Person’s pecuniary interest therein, other than those securities reported herein as being held directly by such Reporting Person.

(b) The address of the principal offices of each Reporting Entity and the business address of Mr. Kutzkey is 1 Letterman Drive, Building D, Suite M-900, San Francisco, CA 94129.

(c) Each of TCG III LP and TCG III-A LP is a venture capital investment entity. TCG III GP LP is the general partner of each of TCG III LP and TCG III-A LP. Mr. Kutzkey, a member of the Board, Peter Svennilson and David Goeddel are the managing members of TCG III GP LP, and are each engaged through venture capital investment entities in acquiring, holding and disposing of interests in various companies for investment purposes

(d) During the past five years, none of the Reporting Persons have been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

(e) None of the Reporting Persons are, nor during the last five years have been, a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

(f) Each of TCG III LP and TCG III-A LP is a limited partnership organized under the laws of the State of Delaware. Mr. Kutzkey is a citizen of the United States of America.

Item 3. Source and Amount of Funds or Other Consideration.

All of the securities reported herein as beneficially owned by the Reporting Persons were acquired pursuant to the Business Combination Agreement by and among, the Issuer, Perseverance Merger Sub Inc. (“Merger Sub”), and Surrozen, Inc. (“Original Surrozen”), dated as of April 15, 2021 (the “Business Combination Agreement”). The Business Combination closed on August 11, 2021 (the “Closing”). Effective upon the Closing, among other things, each share of Original Surrozen’s existing common and preferred stock was automatically cancelled and converted into shares of Common Stock at an exchange ratio of 0.175648535. The above summary is qualified by reference to such description and the full text of the Business Combination Agreement, which is filed as Exhibit 2 to this Statement and is incorporated herein by reference.

Effective upon the Closing, TCG III LP received 4,108,427 shares of the Issuer’s Common Stock in exchange for its equity interests in Original Surrozen and TCG III-A received 4,639,702 shares of the Issuer’s Common Stock in exchange for its equity interests in Original Surrozen (the “Conversion Shares”).

Pursuant to the Terms of the Business Combination Agreement, TCG III LP and TCG III-A LP each purchased units of the Issuer, for $10.00 per unit, with each unit consisting of one share of Common Stock and one-third of one redeemable warrant representing the right to purchase one share of Common Stock at $11.50 per share (the “PIPE Financing”). In the PIPE Financing, TCG III LP received 234,818 shares of Common stock and 78,272 warrants to purchase shares of Common Stock for an aggregate purchase price of $2,348,180 and TCG III-A LP received 265,182 shares of Common Stock and 88,394 warrants to purchase shares of Common Stock for an aggregate purchase price of $2,651,820.

All shares of the capital stock of the Issuer purchased by TCG III LP and TCG III-A LP have been purchased using investment funds provided to TCG III LP and TCG III-A LP by their respective limited partner and general partner investors. Unless noted above, no part of the purchase price was borrowed by any Reporting Person for the purpose of acquiring any securities discussed in this Item 3.

Item 4. Purpose of Transaction.

The information set forth in Item 3 of this Statement is incorporated herein by reference. The Reporting Persons hold the securities of the Issuer for general investment purposes. The Reporting Persons may, from time to time, depending on prevailing market, economic and other conditions, acquire additional shares of Common Stock or other securities of the Issuer, dispose of any such securities, or engage in discussions with the Issuer concerning such acquisitions or dispositions or further investments in the Issuer. The Reporting Persons intend to review their investment in the Issuer on a continuing basis and, depending upon the price and availability of shares of Common Stock or other securities of the Issuer, subsequent developments affecting the Issuer, the Issuer’s business and prospects, other investment and business opportunities available to the Reporting Persons, general stock market and economic conditions, tax considerations and other factors considered relevant, may decide at any time to increase or to decrease the size of their investment in the Issuer in the open market, in privately negotiated transactions, pursuant to 10b5-1 trading plans or otherwise.

Mr. Kutzkey is a member of the Board. In addition, Mr. Kutzkey, in his capacity as a director, may be entitled to receive cash compensation and equity compensation, including stock option or other equity awards pursuant to the Issuer’s 2021 Equity Incentive Plan, filed as Exhibit 3 to this Statement and is incorporated herein by reference.

Except as set forth above, the Reporting Persons have no present plans or intentions which would result in or relate to any of the transactions described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer.

(a) and (b) See Items 7-11 of the cover pages of this Statement and Item 2 above.

(c) Except as reported in this Statement, none of the Reporting Persons has effected any transactions in the Issuer’s securities within the past 60 days.

(d) Under certain circumstances set forth in the limited partnership agreements of TCG III LP and TCG III-A LP the general partner and limited partners of each of TCG III LP and TCG III-A LP may be deemed to have the right to receive dividends from, or the proceeds from, the sale of shares of the Issuer owned by such entity of which they are a partner.

(e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.

The information set forth in Items 3 and 4 of this Statement is incorporated herein by reference.

In connection with the Business Combination, TCG III LP, TCG III-A LP, Mr. Kutzkey and certain of the Issuer’s other investors entered into an Investors’ Rights Agreement, dated August 11, 2021, with the Issuer (the “Rights Agreement”). Upon the closing of the Business Combination, the stockholders party thereto are entitled to certain

registration rights, including the right to demand that that the Issuer file a registration statement or request that their shares be covered by a registration statement that the Issuer is otherwise filing. The terms and provisions of the Rights Agreement are described more fully in the Issuer’s Proxy Statement (File No. 333-256146) (the “Proxy Statement”) and the above summary is qualified by reference to such description and the full text of the Rights Agreement, which is filed as Exhibit 4 to this Statement and is incorporated herein by reference.

The Conversion Shares held by TCG III LP and TCG III-A LP are subject to certain lock-up restriction, which prohibit, subject to certain limited exceptions, the sale, transfer or conveyance of any of the Conversion Shares held by TCG III LP and TCG III-A for 180 days following the closing of the Business Combination. The above summary is qualified by reference to such description and the full text of the Rights Agreement, which is filed as Exhibit 4 to this Statement and is incorporated herein by reference.

In connection with the PIPE Transaction, each of TCG III LP and TCG III-A LP entered into a Unit Subscription Agreement with the Issuer, for the purchase of Units consisting of one share of Common Stock and one-third of one redeemable warrant representing the right to purchase one share of Common Stock at $11.50 per share. The above summary is qualified by reference to such description and the full text of the Unit Subscription Agreement, which is filed as Exhibit 5 to this Statement and is incorporated herein by reference.

The Issuer has entered into an indemnification agreement with each of its directors and executive officers, including Mr. Kutzkey. The indemnification agreement requires the Issuer, among other things, to indemnify Mr. Kutzkey for some expenses, including attorneys’ fees, judgments, fines and settlement amounts incurred by Mr. Kutzkey in any action or proceeding arising out of her service as a director. The terms and provisions of the indemnification agreement are described more fully in the Proxy Statement and the above summary is qualified by reference to such description and the full text of the indemnification agreement which is filed as Exhibit 6 to this Statement and is incorporated herein by reference.

Item 7. Material to be Filed as Exhibits.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

TIM KUTZKEY

Exhibit 1

JOINT FILING AGREEMENT

The undersigned hereby agree that the foregoing statement on Schedule 13D is filed on behalf of each of the undersigned, and any amendments thereto executed by the undersigned shall be filed on behalf of each of the undersigned without the necessity of filing any additional joint filing agreement. The undersigned acknowledge that each is responsible for the timely filing of such statement on Schedule 13D and any amendments thereto, and for the completeness and accuracy of the information concerning him, her or it contained therein, but shall not be responsible for the completeness or accuracy of the information concerning the others of the undersigned, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate or incomplete. This Joint Filing Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument.

TIM KUTZKEY