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                          December 15, 2022

       Craig Parker
       President and Chief Executive Officer
       Surrozen, Inc./DE
       171 Oyster Point Blvd, Suite 400
       South San Francisco, California 94080

                                                        Re: Surrozen, Inc./DE
                                                            Registration
Statement on Form S-3
                                                            Filed December 9,
2022
                                                            File No. 333-268745

       Dear Craig Parker:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Daniel
Crawford at 202-551-7767 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              John T. McKenna, Esq.